2302-25-2, Adding a certain compound to certain chemical reactions, such as: 2302-25-2, name is 4-Bromo-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2302-25-2.
The 2-(4-bromo-lH-imidazol-l-yl)-5-(trifluoromethyl)pyridine was obtained as follows:A dried pressure tube was charged with 4-bromo-lH-imidazole (100 mg, 667 muiotaetaomicron), tetrahydrofuran (3 ml), N,N-dimethylformamide (2 ml), 2-(methylsulfonyl)-5- (trifluoromethyl)pyridine (150 mg, 667 muiotaetaomicron), and cesium carbonate (261 mg, 800 muiotaetaomicron). The tube was sealed and heated at 105 C for 16 hours. For the workup, the reaction mixture was evaporated at reduced pressure and the residue directly purified by chromatography on silica gel using a gradient of heptane/ethyl acetate = 100:0 to 60:30 as the eluent. The 2-(4-bromo-lH- imidazol-l-yl)-5-(trifluoromethyl)pyridine (167 mg, 86% yield) was obtained as a crystalline white solid. MS (ISP): m/z = 292.0 [M+H]+ and 294.2 [M+2+H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1H-imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; SIENA BIOTECH S.P.A.; NARQUIZIAN, Robert; WOLTERING, Thomas; WOSTL, Wolfgang; WO2012/136603; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem