1849-01-0, The chemical industry reduces the impact on the environment during synthesis 1849-01-0, name is 1-Methyl-1H-benzo[d]imidazol-2(3H)-one, I believe this compound will play a more active role in future production and life.
General procedure: One equivalent of appropriate heterocyclic derivative was dissolved in DMF. Three equivalents of potassium carbonate and 1.2 equivalent of the appropriate 3-chloropropan-1-amine derivative were added. The resulting mixture was heated at 70C until disappearance of the starting material. The reaction was monitored by TLC. After 24-96 h, the solvent was removed under reduced pressure, and water added to the residue. The crude product was extracted with dichloromethane. The combined organic fractions were washed with water and dried over magnesium sulphate. Purification by thick layer chromatography or column chromatography was performed.
The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-benzo[d]imidazol-2(3H)-one. I believe this compound will play a more active role in future production and life.
Reference:
Article; Donnier-Marechal, Marion; Carato, Pascal; Le Broc, Delphine; Furman, Christophe; Melnyk, Patricia; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 575 – 582;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem