As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71759-89-2 name is 5-Iodo-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 71759-89-2
After dissolving 4-iodo -1Himidazole(compound 1) (1.9g, 10mmol) in dichloromethane (40mL), under ice-cooling,triethylamine (2.1mL, 15mmol), trityl chloride (3.4g, 12mmol) It was added, under argon, andstirred for 17 hours at room temperature (25 C). After completion of the reaction, water wasadded, and the mixture was extracted twice with dichloromethane. The combineddichloromethane layers were dried anhydrous sodium sulfate and concentrated under reducedpressure, silica and the resulting crude product was gel column chromatography (eluent:chloroform / n-hexane = 1/1 ? chloroform) at Purification, Compound 2 It was obtained (4.1g,9.3mmol, 93% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Iodo-1H-imidazole, and friends who are interested can also refer to it.
Reference:
Patent; Japan Medi-Physics Co., Ltd.; Kyoto University; Okumura, Yuki; Izawa, Akihiro; Akama, Kei; Kobashi, Shinya; Abe, Tsutomu; Saji, Hideo; Kimura, Hiroyuki; (20 pag.)JP2015/93833; (2015); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem