144689-93-0, A common heterocyclic compound, 144689-93-0, name is Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate, molecular formula is C12H20N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthesis of 1 was achieved by literature known method [1, 2]. To a solution of 1 (5 g, 20.82 mmol) in ethanol (50 mL), hydrazine hydrate (3.03 mL, 62.46 mmol) was added. The reaction mixture was refluxed for 16 h for completion of the reaction which was monitored by TLC. Solvent was removed under reduced pressure and cooled by adding ice cold water. The resulting precipitate was filtered, washed with cold water and recrystallized from ethanol to get the desired compound 2.
The synthetic route of 144689-93-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kumara; Suhas; Suyoga Vardhan; Shobha; Channe Gowda; Bioorganic Chemistry; vol. 86; (2019); p. 34 – 38;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem