60-56-0, These common heterocyclic compound, 60-56-0, name is 1-Methyl-1H-imidazole-2(3H)-thione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
150 g of (3-mercaptopropyl) triethoxysilane (manufactured by Tokyo Chemical Industry Co., Ltd.), 85.7 g of limonene (manufactured by Tokyo Chemical Industry Co., Ltd.), 2 g of 2,2′-azobis (isobutyronitrile ) (Manufactured by Wako Pure Chemical Industries, Ltd.) and 300 ml of ethanol were mixed in a recovery flask, bubbled with nitrogen gas for 30 minutes, and reacted at 70 C. for 6 hours.After that, the reaction solution was concentrated to obtain 227 g of a colorless liquid (yield: 97%).To 150 g of the obtained compound, 45.7 g of 1-methylimidazole-2-thiol (manufactured by Wako Pure Chemical Industries, Ltd.), 2 g of 2,2′-azobis (isobutyronitrile) (manufactured by Wako Pure Chemical Industries, ) And 300 ml of ethanol were mixed in a recovery flask, bubbled with nitrogen gas for 30 minutes, and reacted at 70 C. for 6 hours.After that, the reaction solution was concentrated to obtain 185 g of a white solid (yield: 95%).The reaction formula is as follows, and 1-methyl-2-((2-methyl-5-(2-((3-(triethoxysilyl)propyl)thio)propan-2-yl)cyclohexyl)thio)-1H-imidazole.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 60-56-0.
Reference:
Patent; TOYO TIRE & RUBBER COMPANY LIMITED; YURI, TAKASHI; (21 pag.)JP6047434; (2016); B2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem