2849-93-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, A new synthetic method of this compound is introduced below.
To awarm solution of [(eta6-p-cymene)RuI2]2 (49 mg, 0.05 mmol)in ethanol (2.5 mL) a warm solution of HL (16 mg, 0.1 mmol) inethanol (2.5 mL) and triethylamine (13.92 mL), were added. Themixture was stirred at room temperature for 4 h. The orange-redproduct was filtered off, washed with ethanol (4 mL), diethylether and dried in vacuo. Yield: 35.7 mg, 68.4%. Anal. Calcd forC18H19IN2O2Ru, %: C, 41.31; H, 3.66; N, 5.35. Found, %: C, 41.27; H,3.75; N, 5.22. IR (ATR, cm1): 3070(m), 2962(s), 2754(m), 1637(s),1590(m), 1527(s), 1474(s), 1329(s), 1228(m). 1H NMR (199.97 MHz,DMSO-d6, delta, ppm): 14.06 (s, 1H, NH), 7.98 (dd, 1H, JHeH 2.7 and6.5, Hz, CHL), 7.63e7.56 (m, 1H, CHL), 7.55e7.45 (m, 2H, CHL), 5.99(d, 1H, JHeH 5.9 Hz, CHcymene), 5.90 (q, 2H, JHeH 6.3 Hz, CHcymene),5.80 (d, 1H, JHeH 5.9 Hz, CHcymene), 2.81 (m, 1H,JHeH 6.9 Hz, eCH(CH3)2), 2.33 (s, 3H,eCH3), 1.14 (dd, 6H,JHeH 2.8 and 6.9 Hz, eCH(CH3)2). 13C NMR (50.28 MHz, DMSO-d6 ,delta, ppm): 20.27 (eCH3), 22.15 (eCH(CH3)2), 31.55 (eCH(CH3)2),79.05, 80.18, 80.88, 81.08, 86.17 (CHcymene), 96.76 (CeCH3), 103.30(CeCH(CH3)2), 114.12, 118.40, 124.42, 125.69 (CHL), 134.02, 140.90(CeCHL), 145.11 (CeCOO), 163.65 (eCOO). ESI-MS (MeOH): m/z397.049 [M-I]+, 353.059 [M-I-CO2]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Panti?, Darko N.; Arancrossed D Signelovi?, Sandra; Radulovi?, Sini?a; Roller, Alexander; Arion, Vladimir B.; Grguri?-?ipka, Sanja; Journal of Organometallic Chemistry; vol. 819; (2016); p. 61 – 68;,
Imidazole – Wikipedia,
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