In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71759-89-2 as follows. 71759-89-2
N,N’-Dimethylsulfonamide chloride (550 muL, 5.16 mmol) was added to a stirring solution of 4-iodoimidazole (500 mg, 2.58 mmol) and TEA (0.90 mL, 6.44 mmol) in ACN (5 mL) at room temperature. After 2 hours, the mixture was concentrated on silica and subjected to flash column chromatography (10-40% EtOAc/hexane gradient) to afford 4-iodo-imidazole-1-sulfonic acid dimethylamide as white solid (620 mg, 80%). 1H NMR (CDCl3, 300 MHz) delta 1.34 (s, 6H), 5.78 (s, 1H), 6.23 (s, 1H); MS (ESI) m/z=301.9 (MH+).
According to the analysis of related databases, 71759-89-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Genelabs Technologies, Inc.; US2010/204265; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem