These common heterocyclic compound, 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 2849-93-6
A mixture of 1H-benzimidazole-2-carboxylic acid (4.0g, 24.6mmol), aminoethanol (1.48mL, 24.6mmol), 1-hydroxybenzotriazole (4.14g, 27.1mmol) and N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (5.19g, 27.1mmol) in 80mL dimethylformamide was stirred for 12hat room temperature then concentrated in vacuo. The residue could be crystallized from ethanol (35mL). Yield: 3.13g (62%), EI-LRMS m/z 206.1= (M+H)+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2849-93-6.
Reference:
Article; Szabo, Gyoergy; Kolok, Sandor; Orgovan, Zoltan; Vastag, Monika; Beni, Zoltan; Koti, Janos; Saghy, Katalin; Levay, Gyoergy I.; Greiner, Istvan; Keser?, Gyoergy M.; European Journal of Medicinal Chemistry; vol. 186; (2020);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem