Application of 401567-00-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 401567-00-8 name is 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4.1.27. 5-Aminomethyl-2-(4-isopropoxyphenoxy)-1-((2-(trime-thylsilyl)ethoxy)methyl)benzimidazole and 6-aminomethyl-2-(4-isopropoxyphenoxy)-1-((2-(trimethylsilyl)ethoxy)methyl)benzimidazole (24)To a solution of 18 (0.21 g, 0.50 mmol) in 25% aq NH3 (1.6 mL)and EtOH (16 mL) was added Raney Ni (1.6 mL, in water). The mix-ture was stirred for 4 h under a hydrogen atmosphere, then lteredthrough a Celite pad, and the ltrate was concentrated underreduced pressure. The residue was puried by silica gel columnchromatography (CHCl3/MeOH = 8:1) to afford the product 24(0.20 g, 97%, 1:1 regioisomeric mixture) as a yellow oil.1H NMR (500 MHz, CDCl3) d 7.51 (s, 1/2H), 7.48 (d, J = 8.6 Hz,1/2H), 7.43 (s, 1/2H), 7.31 (d, J = 8.0 Hz, 1/2H), 7.24-7.20 (m, 2H),7.19-7.14 (m, 1H), 6.95-6.90 (m, 2H), 5.50 (s, 1H), 5.46 (s, 1H),4.55-4.48 (m, 1H), 3.97 (s, 1H), 3.92 (s, 1H), 3.64 (t, J = 8.3 Hz,1H), 3.63 (t, J = 8.0 Hz, 1H), 1.34 (d, J = 6.0 Hz, 3H), 1.34 (d,J = 6.0 Hz, 3H), 0.93 (t, J = 8.0 Hz, 2H), 0.04 (s, 9/2H), 0.05 (s,9/2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-1H-benzo[d]imidazole-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Article; Okazaki, Shogo; Noguchi-Yachide, Tomomi; Sakai, Taki; Ishikawa, Minoru; Makishima, Makoto; Hashimoto, Yuichi; Yamaguchi, Takao; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5258 – 5269;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem