The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.
In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1-Methyl-1H-imidazole-5-carbaldehyde
Example 18 rac-(3aR,14bR)-10-CyclohexyI-N7-(dimethylsulfamoyl)-13-methoxy-N3a,N3a- dimethyl-2-((l-methyl-lH-imidazol-5-yl)methyl)-l,2,3,14b-tetrahydroindolo[2,l~ a]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide. 1 -Methyl- 1H-imidazole- 5-carbaldehyde (16.3 mg, 0.15 mmol) and then NaCNBH3 (9.3 mg, 0.15 mmol) were added to a slurry of rac-(3aR,14bR)- 10-cyclohexyl-N7-(dimethylsulfamoyl)- 13- methoxy-N3a,N3a-dimethyl-l,2,3,14b-tetrahydroindolo[2,1-alpha]pyrrolo[3,4-d][2]benzazepine-3a,7(4H)-dicarboxamide (30 mg, 0.049 mmol) in MeOH (2 mL). The reaction mixture was stirred at rt for 4h, diluted with THF (1 mL) and treated with additional 1 -methyl- 1H-imidazole-5-carbaldehyde (25 mg). The reaction mixture was stirred at rt for 16h, diluted with DMF (1 mL) and treated with additional NaCNBH3 (10 mg). The reaction mixture was stirred at rt for Id, diluted with MeOH, and purified by preparative HPLC (H2O/MeOH with 0.1% TFA buffer) to yield rac-(3aR,14bR)- 10-cyclohexyl-N7-(dimethylsulfamoyl)- 13-methoxy-N3a,N3a- dimethyl-2-((l -methyl- lH-imidazol-5-yl)methyl)-l ,2,3 , 14b-tetrahydroindolo[2, 1 – alpha]pyrrolo[3,4-d] [2]benzazepine-3a,7(4H)-dicarboxamide (20.2 mg, 0.029 mmol, 58% yield) as a white solid. 1H NMR (300 MHz, CD3OD) delta 1.25 – 1.65 (m, 4H), 1.77 – 2.23 (m, 7H), 2.66 (d, J= 10.6 Hz, IH), 2.94 – 3.07 (m, 2H), 3.05 (s, 6H), 3.10 – 3.35 (m, 6H), 3.51 (d, J= 15.0 Hz, IH), 3.58 (d, J= 15.0 Hz, IH), 3.64 (s, 3H), 3.79 (d,J = 10.6 Hz, IH), 3.91 (s, 3H), 4.04 (d, J= 15.0 Hz, IH), 4.15 (dd, J= 10.6, 7.7 Hz, IH), 4.52 (d, J= 15.0 Hz, IH), 7.06 – 7.15 (m, 3H), 7.41 (d, J= 8.4 Hz, IH), 7.65 (dd, J= 8.4, 1.5 Hz, IH), 7.95 (d, J= 8.4 Hz, IH), 8.03 (d, J= 1.5 Hz, IH), 8.55 (br s, IH). LCMS: m/e 702 (M+H)+, ret time 3.16 min, 4 minute gradient.
The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/120733; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem