These common heterocyclic compound, 3034-50-2, name is Imidazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of Imidazole-4-carbaldehyde
In the step (1) the resulting 1 H – imidazole -4 – formaldehyde reaction solution (0.229 muM) stirring cooling to 25 C, slowly adding hydroxylamine hydrochloride 19.1 g (0.275 muM), 1 H – imidazole -4 – formaldehyde, hydroxylamine hydrochloride in a molar ratio of 1: 1.2, temperature control 30 C, room temperature thermal insulation 2 hours, through the desolvation, shall be viscous […] 4 – a hydroxyimino imidazole (0.227 muM), yield 99%, direct synthesis of the next step.
The synthetic route of Imidazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dalian Qikai Pharmaceutical Technology Co., Ltd.; Han Xiaodong; Zhang Hongxue; Jiang Dianping; (6 pag.)CN109336820; (2019); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem