Adding a certain compound to certain chemical reactions, such as: 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 152628-02-9, Recommanded Product: 152628-02-9
The double-benzimidazole heterocyclic compound (500 mg, 1 . 64mmol) soluble in 20mLN, in N – dimethyl formamide, adding sodium hydrogen (79 mg, 3 . 3mmol) at room temperature under stirring 30min, slow the instillment contains N – O-cyano phenyl -4 – bromo methyl indole (560 mg, 1 . 8mmol) of N, N – dimethyl formamide solution (10 ml) in. The mixed liquid continuing stirring at room temperature instead on invitation 2h, TLC monitoring to the reaction is complete. Filtering, the filter cake is dichloromethane (10 ml ¡Á 3) washing three times. In the filtrate by adding 200 ml of methylene chloride and 200 ml water, takes organically. After the dichloromethane (150 ml ¡Á 3) extracting the aqueous phase three times, the combined organic phase. For saturated salt water (300 ml ¡Á 4) washing the organic phase four. For drying the organic phase with anhydrous magnesium sulfate, filter, evaporate the solvent under reduced pressure, to obtain amber solid. The solid weight crystallized to obtain gray solid about 600 mg (yield is about 68.3%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chen, Zhilong; Zhu, Weibo; Ren, He; Yan, Yijia; Bao, Xiaolu; Chen, Danye; (16 pag.)CN106467521; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem