Adding a certain compound to certain chemical reactions, such as: 33543-78-1, name is Ethyl 1H-imidazole-2-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33543-78-1, HPLC of Formula: C6H8N2O2
To a suspension of ethyl lH-imidazole-2-carboxylate (40.01 g, 285.5 mmol) in dried THF (600 mL) was added sodium hydride (13.82 g, 345.5 mmol, 60 mass%) at 0 C. The mixture was stirred at room temperature for 1 h, and then cooled down to 0 C. To the mixture was added ( -(2,4-dinitrophenyl)hydroxylamine (80.00 g, 401.8 mmol) in portions, and then the resulted mixture was stirred at room temperature overnight. The mixture was diluted with water (600 mL), and the resulted mixture was extracted with EA (600 mLchi10). The combined organic layers were dried over anhydrous Na2SC>4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (EA/PE (v/v) = 1/2 to 1/1 to 2/1) to afford the title compound as a brown solid (37.6 g, yield 85%).MS (ESI, pos. ion) m/z: 156.1 [M + H]+;NMR (400 MHz, CDCb) delta (ppm): 7.19 (s, IH), 7.07 (s, IH), 5.82 (s, 2H), 4.43 (q, J = 7.1 Hz, 2H), 1.44 (t, J = 7.1 Hz, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 1H-imidazole-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Xiaobo; LI, Mingxiong; ZHANG, Tao; HU, Haiyang; WU, Yanjun; (139 pag.)WO2018/169700; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem