Reference of 128293-62-9,Some common heterocyclic compound, 128293-62-9, name is Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, molecular formula is C7H11N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 231: N-[2-(tert-butylcarbamoyl)-1-methyl-1H-imidazol-4-yl]-4,4-dimethyl- l-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7-carboxamide Step 1: Synthesis of ethyl 4-{[(4,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2- a]indol-7-yl)carbonyl]amino}-1-methyl-1H-imidazole-2-carboxylateTo a solution of 4,4-dimethyl-1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-7- carboxylic acid (336 mg, 1.3 mmol, Intermediate E) in DMF (1 mL) are added N- hydroxybenzotriazole (351 mg, 2.6 mmol) and l-ethyl-3-(3-dimethylaminopropyl) carbodiimide (498 mg, 2.6 mmol). After stirring for 10 min, 4-amino-1-methyl-lH- imidazole-2-carboxylic acid ethyl ester (535 mg, 2.6 mmol), N,N-diisopropylethylamine (0.45 mL, 2.6 mmol) and 4-dimethylaminopyridine (32 mg, 0.26 mmol) are added. The reaction mixture is heated at 60 C for 16 h. DMF is removed under a stream of N2 at 40 C and EtOAc (2 mL) and water (2 mL) are added. After stirring for 15min, a white solid is formed and it is filtered and dried to afford the title compound (490 mg, 92%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong; WO2011/71716; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem