Some common heterocyclic compound, 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, molecular formula is C11H10F3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 641571-11-1
A solution of 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline(524 mg, 2.0 mmol) and Et3N (10 mmol) in anhydrous THF (6 mL) wascooled to 0 C in an ice bath. The light yellow solution preparedbefore was then added dropwise. The mixture was allowed to warm toroom temperatureand maintained for 1 h. The reaction mixture was quenched by addition of saturatedNaCl solution and the reaction mixture was extracted several times with EtOAc.Thecombined organic extracts were dried with Na2SO4,filtered, and concentrated in vacuo. The resultant crudematerial was purifiedby column chromatography to give the title compound 7 (873 mg, yield 90% of two steps). 1H NMR (400 MHz, DMSO-d6) d 10.80 (s, 1H), 8.66 (s, 1H),8.47 (d, J = 1.6 Hz, 1H), 8.39 (s, 1H), 8.19 (s, 1H), 7.98 (dd, J = 1.6, 8.0Hz, 1H), 7.79 (s, 1H), 7.66 (s, 1H), 7.53 (d, J = 8.0 Hz ,1H), 2.46 (s, 3H),2.24 (s, 3H). LC-MS (ESI):m/z 486 [M + H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 641571-11-1, its application will become more common.
Reference:
Article; Lu, Xiaoyun; Zhang, Zhang; Ren, Xiaomei; Pan, Xiaofeng; Wang, Deping; Zhuang, Xiaoxi; Luo, Jingfeng; Yu, Rongmin; Ding, Ke; Bioorganic and Medicinal Chemistry Letters; vol. 25; 17; (2015); p. 3458 – 3463;,
Imidazole – Wikipedia,
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