Adding a certain compound to certain chemical reactions, such as: 6160-65-2, name is 1,1′-Thiocarbonyldiimidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6160-65-2, Product Details of 6160-65-2
A solution of the amine (0.1 10 g, 0.43 mmol) in anhydrous CH2CI2 (2 mL) was added dropwise over 2-5 minutes to an ice-salt bath cooled solution of 1 , 1 ‘-thiocarbonyldiimidazole (95%, 0.162 g, 0.87 mmol, 2 eq.) in anhydrous CH2CI2 (6 mL). After 15 minutes, the cooling bath was removed and the reaction mixture was stirred at room temperature for 1 .5 hours after which time analysis by TLC (10% MeOH in CH2CI2) indicated complete consumption of the starting aniline. The mixture was cooled once again in an ice bath and 7 M NH3 in MeOH (620 muIota_, 4.3 mmol, 10 eq.) was added dropwise over 2-5 minutes. The bath was removed and the mixture was stirred over night at room temperature. Silica gel (~1 g) was added and the mixture was concentrated to dryness under reduce pressure. Flash column chromatography (RediSepRf Si02 (40 g), 100% CH2CI2? 10% MeOH in CH2CI2) gave the thiourea as an amber oil that solidified upon standing (0.130 g, 97%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,1’-Thiocarbonyldiimidazole, and friends who are interested can also refer to it.
Reference:
Patent; DUKE UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; LIEDTKE, Wolfgang; STEINHOFF, Martin; GUILAK, Farshid; (150 pag.)WO2016/28325; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem