Synthetic Route of 4856-97-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4856-97-7, name is (1H-Benzoimidazol-2-yl)methanol belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Thionyl bromide is used for some brominations ofcertain ,-unsaturated carbonyls, and it also converts alcohols to alkyl bromides [21]. To asolution of I (5.92 g, 0.04 mol) in 75 mL cyclohexane as a nonpolar solvent and 2 mL N,Ndimethylformamideas a catalyst, was drop wise added thionyl bromide (5 mL).The addition ofN,N-dimethylformamide as a catalyst was found to accelerate the reaction significantly througha Vilsmeier?Haack type SOBr2?DMF complex [22]. The mixture was refluxed for 10 h. Theexcess of thionyl bromide was evaporated under vacuum and residue dissolved in cyclohexaneand washed with water (3¡Á50 mL). The organic layer was dried over sodium sulfate andevaporated to obtain the product (Scheme 1). Beige to dark yellow powder, m.p. 158-162 oC, 89.1percent yield. IR (KBr, cm-1): 3345 (N-H str), 3045 (Ar-C-H str), 2952 (aliphatic C-H str) , 1682(C=N str), 1448 (C=C str), 1292 (C-N str), 667 (C-Br); 1H-NMR (CDCl3, /ppm): 4.64 (s, 2H,CH2),4.89 (s, 1H, NH), 7.20-7.25 (m, 2H, Ar-H), 7.54-7.57 (m, 2H, Ar-H); 13C-NMR (CDCl3,/ppm): 45.1 (CH2-Br), 114.8 (benzimidazole, CH=), 121.6 (benzimidazole, CH=), 135.2(benzimidazole, C), 140.1 (N-C=N). Anal. calcd. for C8H7N2Br: C, 45.50; H, 3.31; N, 13.27percent.Found: C, 45.31; H, 3.28; N, 13.20percent. MS, m/z: 211[M]+.
The synthetic route of (1H-Benzoimidazol-2-yl)methanol has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ahmadi, Abbas; Bulletin of the Chemical Society of Ethiopia; vol. 28; 3; (2014); p. 451 – 456;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem