These common heterocyclic compound, 111851-98-0, name is 1-Ethyl-1H-imidazole-2-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 111851-98-0
General procedure: To a flask equipped with a stir bar and a condenser was added carboxaldehyde (4 mmol, 1.0 equiv), 1- triphenylphosphoranylidene)-2-propanone (4.2 mmol, 1.05 equiv), and toluene (8 mL). The reaction mixture was stirred at 70 C for 5 h. After completion, the reaction mixture was acidified to PH 3 with 1M HCl, and extracted with DCM (15 mL ¡Á 3). The aqueous layer was basified to PH 9 with sodium bicarbonate, and the resulting mixture was extracted with DCM (15 mL ¡Á 3). The DCM extracts from basic aqueous layer were combined, dried over anhydrous magnesium sulfate, and concentrated to give the corresponding (E)-4-(1-alkyl-1H-imidazol-2-yl)but-3-en-2-one.
The synthetic route of 1-Ethyl-1H-imidazole-2-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chen, Qiao-Hong; Yu, Kevin; Zhang, Xiaojie; Chen, Guanglin; Hoover, Andrew; Leon, Francisco; Wang, Rubing; Subrahmanyam, Nithya; Addo Mekuria, Ermias; Harinantenaina Rakotondraibe, Liva; Bioorganic and Medicinal Chemistry Letters; vol. 25; 20; (2015); p. 4553 – 4556;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem