Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3034-38-6, name is 5-Nitro-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 3034-38-6
General procedure: The opportune alkyl bromide (916 mg, 4.26 mmol) was added to a solution of 4-nitro-1H-imidazole5 (438 mg, 3.87 mmol) in acetonitrile (3 mL) and potassium carbonate (803 mg, 5.81 mmol).The resulting mixture was heated at 60 C overnight. The reaction mixture was then filtered, andthe filtrate was concentrated in vacuum, leaving a yellow solid. The desired product was recoveredfrom this residue by normal phase column chromatography on a cartridge Biotage HP-SiO2 (50 g)column primed with DCM only. The column was then run for 4CV with DCM and then changed toDCM/MeOH 9:1 over 5CV.1-[2-(2-Methoxyphenyl)ethyl]-4-nitro-1H-imidazole (6a): White solid, 82% yield, mp: 100-102 C; IR: nu= 1338 (NO) cm-1; 1H NMR (400 MHz, DMSO-d6) delta = ppm 3.11 (t, J = 7.34 Hz, 2H), 3.75 (s, 3H), 4.28(t, J = 7.34 Hz, 2H), 6.84 (t, J = 7.34 Hz, 1H) 6.93-7.06 (m, 2H), 7.19-7.26 (m, 1H), 7.67 (s, 1H), 8.30 (s, 1H); 13C NMR (100 MHz, DMSO-d6) delta = ppm 158.8, 146.2, 138.7, 129.9, 128.4, 126.8, 121.5, 120.4, 112.9,56.8, 49.6, 28.6; HRMS (ESI): m/z calcd. for C12H13N3O3 248.9567 [M + H]+, found 248.9542.
According to the analysis of related databases, 3034-38-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Francini, Cinzia Maria; Musumeci, Francesca; Fallacara, Anna Lucia; Botta, Lorenzo; Molinari, Alessio; Artusi, Roberto; Mennuni, Laura; Angelucci, Adriano; Schenone, Silvia; Molecules; vol. 23; 9; (2018);,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem