In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3034-38-6 as follows. name: 5-Nitro-1H-imidazole
Step A Preparation of 4-nitro-1-(triphenylmethyl)imidazole To a solution of 4-nitroimidazole (7.28, g, 64.4 mmol) in 60 mL of dry DMF at 0 C. was added triethylamine (9.87 mL, 70.8 mmol), then chlorotriphenylmethane (17.95 g, 64.4. mmol). After 5 minutes, the solution was warmed to room temperature. After 30 minutes, the reaction mixture was poured over ice, filtered, and washed with ice water. The resulting product was dried in vacuo next to P205 to provide the titled product as a white powder (22.29 g, 97% yield) which was sufficiently pure for use in the next step.
According to the analysis of related databases, 3034-38-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Merck & Co., Inc.; US5859012; (1999); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem