In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2403-66-9, name is 3-(1H-Benzo[d]imidazol-2-yl)propan-1-ol belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: imidazoles-derivatives
In a 300 ml recovery flask, 17.62 g (100.0 mmol) of 2- (3-hydroxypropyl) benzimidazole,22.26 g (220.0 mmol) of triethylamine, 0.22 g (1.0 mmol) of 3,5-di-tert-butyl-4-hydroxytoluene and 200 ml of tetrahydrofuran were added to prepare a reaction solution. After the reaction solution was cooled to 0 C., 23.00 g (220.0 mmol) of methacryloyl chloride was added dropwise and the mixture was stirred at room temperature for 3 hours, and the precipitated triethylamine hydrochloride was filtered off.Then, the filtrate was concentrated and 200 ml of methanol and 0.54 g (10.0 mmol) of sodium methoxide were added to the solution to prepare a solution, and the mixture was stirred at room temperature for 1 hour. Subsequently, this solution was concentrated and extraction operation with 100 ml of ethyl acetate was carried out three times, and the extracted solutions were mixed and concentrated to obtain a dry matter. This dry matter was dissolved in ethyl acetate 10 mlAnd 10 ml of hexane to obtain 14.48g (yield: 59%) of white crystals.
The synthetic route of 2403-66-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHIKOKU CHEMICALS CORPORATION; OKUMURA, NAOTO; IKEDA, YUICHI; (27 pag.)JP2015/20962; (2015); A;,
Imidazole – Wikipedia,
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