33529-02-1, name is 1-Decyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: imidazoles-derivatives
4-Vinylbenzyl chloride (1.00 g, 6.55 mmol) and 1-decylimidazole (1.50 g, 7.20 mmol) were stirred in acetonitrile (40 mL) at reflux for 18 h. Upon cooling, the reaction mixture was concentrated to form a yellow viscous oil and washed with Et2O (3 ¡Á 40 mL). The resulting oil was then dissolved in H2O (40 mL). LiTf2N (2.26 g, 7.87 mmol) was added, and then the resulting mixture stirred at room temperature for 12 h. A yellow oil was then extracted from this aqueous mixture with CH2Cl2 (3 ¡Á 50 mL). The CH2Cl2 layer was then washed with H2O (3 ¡Á 100 mL), dried over anhydrous MgSO4, filtered, and concentrated to give monomer 2c as a light yellow oil (yield: 3.49 g, 88%). 1H NMR (300 MHz, CDCl3): delta8.88 (s, 1H), 7.44 (d, J = 8.2 Hz, 2H), 7.33 (d, J = 8.2 Hz, 2H), 7.24 (dt, J = 12.0, 2.0 Hz, 2H), 6.69 (dd, J = 17.6, 10.9 Hz, 1H), 5.78 (d, J = 17.6, 1H), 5.31 (d, J = 10.8, 1H), 5.31 (s, 2H), 4.16 (t, J = 7.4 Hz, 2H), 1.93-1.76 (m, 2H), 1.39-1.17 (m, 14H), 0.87 (t, J = 7.0 Hz, 3H). 13C NMR (75 MHz, CDCl3): delta139.19, 135.83, 135.58, 131.69, 129.29, 127.41, 122.45, 122.24, 122.08, 117.82, 115.76, 53.46, 50.49, 31.95, 30.18, 29.51, 29.40, 29.34, 28.96, 26.24, 22.77, 14.21. IR (neat): 3146.88, 2927.24, 2856.85, 1560.77, 1456.43, 1348.21, 1182.03, 1133.87, 1053.89, 990.02, 914.86, 830.80, 788.70, 739.55, 653.29. HRMS (ES) calcd. for C24H33F6N3O4S2 (M+ Tf2N-): 605.1817; observed: 605.2435. Since imidazolium-based ionic liquid compounds are known in the literature to have combustion issues for C, H, and N elemental analysis [34], the 1H and 13C NMR spectra for isolated 2c are provided in the Supplementary Data to help confirm its purity.
The synthetic route of 33529-02-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shi, Zhangxing; Newell, Brian S.; Bailey, Travis S.; Gin, Douglas L.; Polymer; vol. 55; 26; (2014); p. 6664 – 6671;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem