Application of 670-96-2,Some common heterocyclic compound, 670-96-2, name is 2-Phenyl-1H-imidazole, molecular formula is C9H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Placing 2-phenylimidazole in an amount of 8.6 g (60 mmol) into a flask having a dropping funnel, and after replacing the atmosphere with argon gas, 180 milliliter of tetrahydrofuran was added. Under cooling with ice, n-butyllithium of 1.56 mol/liter in an amount of 39.1 milliliter (61 mmol) was dripped down into the solution spending 30 minutes and subsequently, 8.6 g(61 mmol) of methyl iodide dissolved into 10 milliliter of tetrahydrofuran was dripped down. After termination of dripping down, the resultant solution was reacted at the room temperature for 3 hours. Concentrating the reacted solution and extracting the resultant solid using 150 milliliter of methylene chloride, it was washed three times using 150 milliliter of water. After drying an organic layer with the use of magnesium sulfate, the solvent was removed. Refining the crystals by means of silicagel column (hexane / methylene chloride), 6.1 g of 1-methyl-2-phenylimidazo Intermediate6-1b as white crystals was obtained (yield: 69 %). The white crystals were confirmed as the aimed compound from 1H-NMR spectrum. The measurement result is shown as follows: 1H-NMR(CDCl3): delta 7.29-7.67 (m,5H), delta 6.93-7.10 (m,2H), delta 3.69 (s,3H)
The synthetic route of 670-96-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDEMITSU KOSAN CO., LTD.; EP1647554; (2006); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem