In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. name: 1-Methyl-1H-imidazole-5-carbaldehyde
A mixture of D100 (30.mg, 0.09mmol) and 1-methyl-1H-imidazole-5-carbaldehyde (52mg,0.47mmol) in IPA (2mL) was treated with 4N HCl in dioxane (22.5uL, 0.61mmol) and heated at70C for 5min. Solvent was removed in vacuo and the residue purified by preparative HPLC(HzO,CH3CN 0.1% HCOOH, giving the title compound E37 (17mg) as white solid. Method 3; Rt:2.54min. m/z: 438.11 (M+Ht. 1H NMR (300 MHz, DMSO-d6) 8 ppm 3.70 (s, 3 H) 6.08 (br d,1=7.79 Hz, 1 H) 7.08 (d, 1=8.89 Hz, 1 H) 7.18 (s, 1 H) 7.64- 7.84 (m, 3 H) 7.96 (dd, 1=8.80, 2.02Hz, 1 H) 8.18 (br s, 2 H) 8.32 (d, 1=1.83 Hz, 1 H) 10.44 (s, 1 H)
The synthetic route of 39021-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; OSPEDALE SAN RAFFAELE S.R.L.; IRBM S.P.A.; PROMIDIS S.R.L.; ISTITUTO NAZIONALE DI GENETICA MOLECOLARE – INGM; DE FRANCESCO, Raffaele; DONNICI, Lorena; GUIDOTTI, Luca; IANNACONE, Matteo; DI FABIO, Romano; SUMMA, Vincenzo; BENCHEVA, Leda Ivanova; DE MATTEO, Marilenia; FERRANTE, Luca; PRANDI, Adolfo; RANDAZZO, Pietro; (238 pag.)WO2020/16434; (2020); A1;,
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