Related Products of 3752-24-7,Some common heterocyclic compound, 3752-24-7, name is 4,5,6,7-Tetrahydro-1H-benzo[d]imidazole, molecular formula is C7H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of Intermediate 1 (2.1 g, 17 mmol) in DMF (6 mL) were added 2- (chloromethyl)-l,4-dimethylbenzene (2.6 g, 17 mmol) and potassium carbonate (4.8 g, 35 mmol). The mixture was stirred overnight at room temperature. Water (5 mL) was added and the mixture was stirred for another 10 minutes. The reaction mixture was poured into ethyl acetate/water and the layers were separated. The organic layer was washed three times with brine, then dried over magnesium sulphate and concentrated by evaporation in vacuo, to afford the title compound (1.2 g, 29%) as a pale yellow solid, deltapi (400 MHz, d6- DMSO) 7.40 (s, IH), 7.07-7.09 (m, IH), 7.00 (d, 77.6 Hz, IH), 6.57 (s, IH), 5.02 (s, 2H), 2.50-2.51 (m, 3H), 2.31-2.35 (m, 2H), 2.22 (s, 3H), 2.20 (s, 3H). LCMS (ES+) 241 (M+H)+, RT 1.46 minutes (method A).
The synthetic route of 3752-24-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UCB BIOPHARMA SPRL; HEER, Jag Paul; JACKSON, Victoria Elizabeth; KROEPLIEN, Boris; LECOMTE, Fabien Claude; PORTER, John Robert; WO2015/86513; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem