Application of 152628-03-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 152628-03-0, name is 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
The compound IIc (534 mg, 2.45 mmol)Was slowly added to polyphosphoric acid (15 mL) heated to 80 C,Stirred and heated to 150 C.Compound IIIb (320 mg, 2.94 mmol) was added slowly to the former polyphosphoric acidAfter the addition was complete, the reaction was stirred at 150 C for 12 h. After completion of the reaction, the reaction solution was poured into 100 mL of ice water,And adjust the pH to 8-10 with concentrated ammonia, there will be a large number of precipitation, filtration, filter cake with 5% ethanol solution washed three times. To be filteredAfter drying the cake, the resulting filter cake was purified by chromatography to give about 357 mg (yield 58.7%) of the pale yellow compound IVb.
The chemical industry reduces the impact on the environment during synthesis 4-Methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Donghua University; Chen Zhilong; Bao Xiaolu; Zhu Weibo; Wu Zhuo; Zhang Ruijing; Ren He; Zhang Jinyan; Zhu Xingbo; Zhou Huayuan; Tang Hesheng; Yu Xinhai; Yan Yijia; (15 pag.)CN106749220; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem