Application of 705-09-9, These common heterocyclic compound, 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 14a (300mg, 1.8mmol, leq) in DMF(4mL) was added NaH(60%, 75mg, 1.8mmol, leq) at 0~5C. The resulting mixture was stirred for 30min at 0~5C and to the mixture was added 68b(459mg, l.deltammol, leq) portion- wise. The reaction mixture was stirred at r.t. over a weekend. The solvent was removed and the residue was purified by column chromatography (PE:EA=4: 1) to give 68c (33Omg, yield: 50%) as a colorless oil. ES-MS m/z: 377 (M++l)
Statistics shows that 2-(Difluoromethyl)-1H-benzo[d]imidazole is playing an increasingly important role. we look forward to future research findings about 705-09-9.
Reference:
Patent; XCOVERY, INC.; LIANG, Congxin; LI, Zhi-Gang; WO2010/5558; (2010); A2;,
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