Related Products of 760212-58-6, These common heterocyclic compound, 760212-58-6, name is 1-(4-Bromophenyl)-2-phenyl-1H-benzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a one-neck 250 mL flask2.5 g (4.54 mmol) of Intermediate 4, 1.59 g (4.54 mmol) of Int.4, 0.16 g (0.14 mmol) of Pd (PPh3) 4, 1.26 g (9.08 mmol) of K2CO3,50 mL of toluene, 20 mL of ethanol and 10 mL of water were mixed and stirred for 11 hours while heating and refluxing.After the reaction was completed, the solvent was distilled off under reduced pressure, diluted with 50 mL of CHCl3 and filtered using celite.Washed with 100 mL of CHCl3, concentrated under reduced pressure, and purified by silica gel column chromatography to obtain 2.0 g (yield: 64.5%) of 4-42 (WS15-30-305) as a white solid.
The synthetic route of 760212-58-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lapto Co., Ltd.; MOON, Seong-shik; SEOK, Moon-ki; GO, Byung-soo; KIM, Nam-ho; KWAK, Se-young; HAN, Gab-jong; OH, Eu-gene; (38 pag.)KR2017/103574; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem