Electric Literature of 10040-98-9, The chemical industry reduces the impact on the environment during synthesis 10040-98-9, name is 4-Imidazol-1-yl-benzaldehyde, I believe this compound will play a more active role in future production and life.
A mixture of malonitrile (60.0 mg, 0.90 mmol) and 4-(1H-imidazol-1- yl)benzaldehyde (155.0 mg, 0.90 mmol) in anhydrous ethanol ( 4.0 mL) was charged with N- methylmorpholine (0.1 mL, 0.90 mmol) for 2 minutes. To the mixture was added 3-(4- methoxyphenyl)-1-methyl-1H-pyrazol-5(4H)-one (185.0 mg, 0.90 mmol) in one portion at room temperature. The reaction mixture was stirred at room temperature for 48 hrs. The suspension was filtered under vacuum and off white solid was obtained. The solid was gently washed with hexanes (20 mL) and chilled ethanol (10 mL) and further dried under high vacuum to provide compound 48 as an off white solid (360 mg, 94%).1H NMR (400 MHz, DMSO-d6) delta (ppm): 8.18 (s, 1H), 7.68 (s, 1H), 7.52-7.46 (m, 4H), 7.27 (d, J = 8.0 Hz, 2H), 7.13 (s, 2H), 7.06 (s, 1H), 6.78 (d, J = 8.0 Hz, 2H), 5.06 (s, 1H), 3.77 (s, 3H), 3.69 (s, 3H). MS (ESI): Calcd for C24H20N6O2: 424, found: 424 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Imidazol-1-yl-benzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NANTBIOSCIENCE, INC.; TAO, Chunlin; YU, Chengzhi; POLAT, Tulay; YAN, Chao; RABIZADEH, Shahrooz; THEODORESCU, Daniel; (108 pag.)WO2016/205460; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem