Related Products of 17289-19-9, These common heterocyclic compound, 17289-19-9, name is Methyl 1-methyl-1H-imidazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of methyl 1-methyl-1H-imidazole-4-carboxylate (14.3 mmol, 2 g) in CCl4 (40 mL), NBS (15.3 mmol, 2.72 g) and AIBN (0.715 mmol, 117 mg) were added. The reaction mixture was heated for 4 h at 60 C and then cooled to RT. The solvent was evaporated. The reaction crude was purified by flash chromatography over silica gel using an elution of 8% methanol in ethyl acetate to afford 529 mg (Yield: 17%) of the title compound 18. 1H NMR (400 MHz, CDCl3): delta 7.59 (1H, s), 3.91 (3H, s), 3.67 (3H, s); ESI-MS: m/z 219 [M + H]+
The synthetic route of 17289-19-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nino, Patricia; Caba, Marta; Aguilar, Nuria; Terricabras, Emma; Albericio, Fernando; Fernandez, Joan-Carles; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 9; (2016); p. 1117 – 1130;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem