Electric Literature of 2849-93-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2849-93-6, name is 1H-Benzimidazole-2-carboxylic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 1H-benzo[djimidazole-2-carboxylic acid (161 mg, 990 imol, 1.2 eq) in 2 mL of DMF was added HATU (377 mg, 990imol, 1.2 eq) and TEA (167 mg, 1.6 mmol, 229 tL, 2.0 eq). The mixture was stirred at 15 Cfor 0.5 hour, then tert-butyl N-[(1R,3S)-3-(ethylamino)cyclohexylj carbamate, compound 2,(200 mg, 825 imol, 1.0 eq) was added and the resulting reaction mixture was stirred at 15 Cfor additional 15.5 hours. The reaction mixture was partitioned between 5 mL of water and 5 mL of ethyl acetate. The organic phase was separated, washed twice with 10 mL of brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give an oil. The oil was purified by prep-TLC (Si02, eluting with petroleum ether: ethyl acetate = 1:1) to give 150mg of compound 65 (388 imol, 47% yield) as a colorless gum.
The synthetic route of 1H-Benzimidazole-2-carboxylic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Imidazole – Wikipedia,
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