Reference of 5805-53-8, These common heterocyclic compound, 5805-53-8, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of lH-benzoimidazole-2-carboxylic acid methyl ester (18) (0.89 g, 5.1 mmol) in 2 N aq. NaOH (10 mL) and MeOH (10 mL) was stirred at RT for 18 h. The mixture was acidified to pH = 4 with 1 N aqueous HCl. The mixture was extracted with EtOAc. The organic layer was washed with brine, dried over Na2S04 and evaporated to obtain compound (19) as a brown solid (0.67 g, yield 80%). ESI-MS (M+l): 163 calc. for C8H6N202 162.
Statistics shows that Methyl 1H-benzo[d]imidazole-2-carboxylate is playing an increasingly important role. we look forward to future research findings about 5805-53-8.
Reference:
Patent; AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge; WO2011/143365; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem