Reference of 98873-55-3, The chemical industry reduces the impact on the environment during synthesis 98873-55-3, name is 2-(1H-Imidazol-1-yl)acetonitrile, I believe this compound will play a more active role in future production and life.
10.9 g of potassium hydroxide was added to 200 ml of dimethylsulfoxide,A solution prepared by dissolving 7.5 g of 1-cyanomethylimidazole and 5.2 g of carbon disulfide in 100 mL of dimethyl sulfoxide under cooling in a water bath was added dropwise thereto,And stirred at room temperature for 1 hour to prepare a dithiolate solution.Subsequently, under cooling in a water bath, the resultant dithiolate solution was added to 200 mL of dimethylsulfoxide, 26.1 g of the crude product (S) -1- (2,4-dichlorophenyl) -ethan-1,2-bismethanesulfonate Was added dropwise to the solution.After stirring at room temperature for 2 hours, the reaction mixture was poured into ice water and extracted with ethyl acetate. The organic layer was washed with water,After drying over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure.The residue was purified by silica gel column chromatography (ethyl acetate / hexane = 2/1).The resulting crystals were dissolved in ethyl acetate,Hexane mixed solvent to obtain 5.1 g (the yield: 21%) of the desired product.The purity of the product is 99.66%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(1H-Imidazol-1-yl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kyongbo Pharmaceutical Co., Ltd.; Son, Hwe Joo; Kim, Young Taek; Oh, Do Yeon; Kim, Sung Ho; (9 pag.)KR2016/61542; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem