Electric Literature of 360-97-4, These common heterocyclic compound, 360-97-4, name is 4-Amino-1H-imidazole-5-carboxamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(b) tert-Butyl {2-[(5-carbamoyl-lH-irnidazol-4-yl)amno]-l-methylethyl}comega’bamate; To a stirred solution tert-butyl (l-methyl-2-oxoethyl-carbamate (0.82 g, 4.8 mmol, obtained from Example 29(a)) in ethanol (10 mL) was added 5-aminoimidazole-4- carboxamide (9.4 mL, 67 mmol). After 1 h, glacial acetic acid (0.28 mL, 4.0 mmol) was added. After another 1 h, sodium cyanoborohydride (0.48 g, 4.0 mmol) was added. After 20 h, the solvent was removed in vacuo. The product was purified by silica gel column chromatography (dichloromethane / methanol, 95:5 then 90:10) to give the title compound (0.95 g, 66% yield) as a solid.1H NMR (CDCl3) delta ppm 7.17 (IH), 6.51 (IH), 4.71 (IH), 3.57-3.46 (IH), 3.40 (IH)5 3.06- 2.96 (IH)5 1.48 (9H)5 1.25 (3H); MS (ESI) m/z 284 (M+l).
Statistics shows that 4-Amino-1H-imidazole-5-carboxamide is playing an increasingly important role. we look forward to future research findings about 360-97-4.
Reference:
Patent; ASTRAZENECA AB; WO2007/120098; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem