Reference of 36947-68-9, A common heterocyclic compound, 36947-68-9, name is 2-Isopropyl-1H-imidazole, molecular formula is C6H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Isopropyl-1H-imidazole (600 mg, 5.45 mmol) was dissolved in 1,4-dioxane (6 mL)-2-methoxyethanol (6 mL), N-chlorosuccinimide (1.0 g, 7.51 mmol) was added, and the mixture was heated at room temperature for 30 min. N-chlorosuccinimide (450 mg, 3.38 mmol) was further added, and the mixture was stirred at room temperature for 1 hr. Water was added to the mixture, and the precipitated crystals were collected by suction filtration to give 4,5-dichloro-2-isopropyl-1H-imidazole (477 mg, 49%). ESIMS m/z: 179 (M + H)+; 1H NMR (270 MHz, CDCl3, delta): 1.32 (d, J = 7.2 Hz, 6H), 2.89-3.11 (m, 1H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; YAMAMOTO, Keisuke; TAMURA, Tomohiro; NAKAMURA, Rina; UENO, Kimihisa; HOSOE, Shintaro; EP2740730; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem