In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 85330-50-3 as follows. Application In Synthesis of 4-Nitro-1H-benzo[d]imidazol-2(3H)-one
b)Preparation of 4-amino-benzimidazolin-2-one To a solution of 4-nitro-benzimidazolin-2-one (700 mg, 3.9mmol) in methanol(50 ml) and acetic acid (10 ml) was added 10% Pd/C (200 mg). The mixture was flushed with argon, then hydrogen was bubbled through the solution for 10 ain. and a hydrogen atmosphere was maintained at balloon pressure overnight. The mixture was filtered through celite and the celite was washed with methanol. The solvent was evaporated and chromatography of the resulting solid on silica gel (10%MeOH/CH2C2) gave the desired product (500 mg, 86%). 1H NMR (CD3SO2CD3): delta10.34 (s, 1H), 10.01 (s, 1H), 6.66 (t, 1H), 6.24 (d,1H), 6.22 (d, 1H), 5.15 (bs, 2H).
According to the analysis of related databases, 85330-50-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SmithKline Beecham Corporation; US6300325; (2001); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem