Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89830-98-8, name is 5-Cyclopropyl-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H8N2
[00641] A mixture of Example 134b (100 mg, 0.235 mmol), Example 134c (108 mg, 1.0 mmol), K2C03 (162 mg, 1.175 mmol), Cul (11 mg, 0.058 mmol) in dry DMSO (2 mL) was heated at 125¡ãC for 24 h. The reaction was cooled to r.t., and water (25 mL) was added. The resulting mixture was stirred for 5 min, and filtered to give the crude product, which was purified by prep-HPLC (by Ultimate XB-C18, 50 x 250 mm, 10 muetaiota, speed: 80 mL/min, eluent: A/B = H20/CH3C = from 75/25 to 45/55 over 30 min. Ret. Time =: 24.94 min), followed by prep-TLC (DCM/MeOH = 10/1) to give the desired product Example 134 (1.2 mg, yield 1percent) as a white solid. LC-MS [M+l]+ = 454.0. NMR (400 MHz, Chloroform-d) delta 11.80 (s, 1H), 8.23-8.15 (m, 3H), 8.04 (s, 1H), 7.97 (t, J= 7.9 Hz, 1H), 7.83 (s, 1H), 7.50 (s, 2H), 7.12 (s, 1H), 4.83 (t, J= 8.9 Hz, 1H), 4.58 (s, 2H), 4.41 (t, J= 6.9 Hz, 1H), 3.81 (s, 2H), 2.88 (s, 2H), 1.96 (d, J= 38.7 Hz, 1H), 0.89 (d, J= 7.0 Hz, 2H), 0.83 (s, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (214 pag.)WO2019/51265; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem