Adding a certain compound to certain chemical reactions, such as: 39070-14-9, name is (1-Methyl-2-nitro-1H-imidazol-5-yl)methanol, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39070-14-9, Recommanded Product: 39070-14-9
EXAMPLE 1 78.5 g of 1-methyl-2-nitroimidazole-5-methanol were suspended in 1.5 l of anhydrous tetrahydrofuran. After the addition of 102 g of p-chloroacetylaminophenol and 144 g of triphenylphosphane, the mixture was cooled to 10 C. and a solution of 111 g of diisopropyl azodicarboxylate in 750 ml of anhydrous tetrahydrofuran was added thereto with vigorous stirring within 20 minutes, the temperature being held at 10-12 C. by means of an ice-bath. The mixture was stored in a refrigerator overnight and the crystalline precipitate was filtered off under suction. Recrystallization from 2 l of acetonitrile, yielded 90.9 g (56.6%) of pure 2-chloro-alpha-(1-methyl-2-nitroimidazol-5-yl)-p-acetanisidide, m.p. 192-194 C. (decomposition).
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Reference:
Patent; Hoffmann-La Roche Inc.; US4515790; (1985); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem