Some common heterocyclic compound, 17325-26-7, name is Methyl 1H-imidazole-5-carboxylate, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H6N2O2
To a solution of methyl 1H-imidazole-4-carboxylate (3.78 g, 30 mmol) in anhydrous THF (60 mL) was added sodium hydride (0.72 g, 30 mmol). The solution was then stirred at room temperature for 1 h before addition of 2-bromoacetonitrile (4.2 g, 35 mmol). The reaction was stirred at room temperature for 2 h before being concentrated in vacuo. The crude residue was purified on silica gel (petroleum ether:ethyl acetate=3:1) to afford the desired product (2.48 g, 50% yield). MS m/z: 166 [M+H+].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17325-26-7, its application will become more common.
Reference:
Patent; Albrecht, Brian K.; Bellon, Steven F.; Gehling, Victor S.; Harmange, Jean-Christophe; LeBlanc, Yves; Liang, Jun; Magnuson, Steven; Tsui, Vicki; Zhang, Birong; US2015/65522; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem