Related Products of 705-09-9, A common heterocyclic compound, 705-09-9, name is 2-(Difluoromethyl)-1H-benzo[d]imidazole, molecular formula is C8H6F2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3: 1 : To a solution of 6c (1.92g, 6.98mmol) in DMF (20mL) was added NaH (307mg, 7.68mmol) under ice bath. The resulting mixture was stirred at 0-50C for 30min and was added 3a (1.17g, 6.98mmol). The reaction mixture was stirred at r.t. for 2.5h and evaporated. The residue was dissolved in morpholine (30mL) and heated at 800C for 2h. After cooling to room temperature, the mixture was added IN NaOH (28mL). The resulting mixture was stirred at r.t. for 2h, evaporated. The residue was purified by column chromatography (PE:EA=1:1) to give 6 (660mg, 23% yield from 6c). 1H NMR(300MHz, CDCl3): delta=3.45 (t, 1H), 3.78-3.94 (m, 8H), 4.12-4.17 (m, 2H), 4.52-4.56 (m, 2H), 7.18 (t, 1H), 7.42-7.56 (m, 3H), 7.78 (s, 1H), 7.95-7.98 (m, 1H). LC-MS [M+H]+: 416.0.
The synthetic route of 705-09-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TYROGENEX, INC.; LIANG, Congxin; LI, Zhigang; WO2010/56320; (2010); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem