Some common heterocyclic compound, 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, molecular formula is C4H5ClN2O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Methyl-1H-imidazole-4-sulfonyl chloride
Example 227 1-methyl-N-[3-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-4-phenoxyphenyl]-1H-imidazole-4-sulfonamide [1006] The product from Example 225C (0.044 g, 0.15 mmol), 1-methyl-1H-imidazole-4-sulfonyl chloride (0.033 g, 0.180 mmol) and triethylamine (0.042 mL, 0.30 mmol) were combined in dichloromethane (0.75 mL), heated at 60 C. for 2 hours and concentrated. Purification by chromatography (silica gel, 0-3% methanol in dichloromethane) afforded the title compound (0.038 g, 56%). 1H NMR (300 MHz, DMSO-d6) delta 10.21 (s, 1H) 7.84 (d, J=1.36 Hz, 1H) 7.75-7.78 (m, 2H) 7.48 (dd, J=9.49, 2.71 Hz, 1H) 7.25-7.35 (m, 2H) 7.21 (d, J=2.71 Hz, 1H) 7.09 (dd, J=8.82, 2.71 Hz, 1H) 7.03 (t, J=7.46 Hz, 1H) 6.89 (d, J=8.82 Hz, 1H) 6.83 (d, J=7.80 Hz, 2H) 6.37 (d, J=9.49 Hz, 1H) 3.67 (s, 3H) 3.43 (s, 3H). MS (ESI+) m/z 437 (M+H)+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 137049-00-4, its application will become more common.
Reference:
Patent; HUBBARD, Robert D.; WANG, Le; PARK, Chang H.; SUN, Chaohong; McDANIEL, Keith F.; PRATT, John K.; SOLTWEDEL, Todd N.; WENDT, Michael D.; HOLMS, John H.; LIU, Dachun; SHEPPARD, George S.; US2013/331382; (2013); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem