Electric Literature of 128293-62-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 128293-62-9, name is Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To Im-3 (0. 38 g) in DMF (8 mL) and Hunig’s base (2ML) was added ditert-butyl dicarbonate (0.7 ml) and the mixture stirred at 60 C for 3 hr. It was then cooled to room temperature and brine (6 ML) and ethyl ether (6 ML) were added. The ether layer was extracted with 10% citric acid, brine, saturated sodium bicarbonate, and brine (10 mL each). The ether layer was then dried over sodium sulfate and evaporated under vacuum. NAOH (1M, 5mL) in methanol was then added and solution stirred at 60 C for 1 hr. The mixture was then cooled to 0 C and neutralised with 1M HC1 to pH 2 at which a white gel was formed. The gel was collected by gravity filtration and washed with water pH=6 before it was freeze dried to yield the product as a white powder. Yield (0.41 g, 76%). 1H NMR (DMSO): 6 9.45 (bs, 1H, NH), 7.21 (bs, 1H), 3. 86 (s, 3H), 3.67 (bs, 1H, OH), 1.4 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITY OF WESTERN SYDNEY; WO2005/33077; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem