Adding a certain compound to certain chemical reactions, such as: 4857-06-1, name is 2-Chloro-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4857-06-1, Safety of 2-Chloro-1H-benzo[d]imidazole
[1372] mel (6.1 ml, 98.3 mmol) was added to a mixture of 2-chloro-1H-benzo[d]imidazole (5.0 g, 32.8 mmol) and K2CO3 (13.6 g, 98.3 mmol) in DMF(20 ml). The mixture was stirred at 25 C for lh. The insoluble substance was removed by filtration and the filtrate was treated with ea (50 ml), H2O (50 ml). The organic layer was separated and the aqueous layer was extracted with ea (35 ml x 3). The combined organic layer was washed with H2O (35 ml x 2), brine (35 ml x 2), dried over mgs04, filtered and concentrated. The residue was triturated with tbme/pe (v/v = 1/1, -20 ml) to afford compound 294a (3.3 g, yield 60.38%) as pale yellow solid. 1H NMR (DMSO-d6, 400 mhz) delta .60 – 7.56 (m, 2h), 7.31 – 7.24 (m, 2h), 3.80 (s, 3h). MS (ESI) m/z (M+H)+ 167.0.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem