Synthetic Route of 152628-02-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 152628-02-9, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, SMILES is C(CC)C1=NC2=C([NH]1)C(=CC(=C2)C3=NC4=C([N]3C)C=CC=C4)C, belongs to imidazoles-derivatives compound. In a article, author is PEDERSEN, M, introduce new discover of the category.
FORMATION AND ANTIMYCOTIC EFFECT OF CYCLODEXTRIN INCLUSION COMPLEXES OF ECONAZOLE AND MICONAZOLE
The stability constants between beta-cyclodextrin (beta-CD) and the two antimycotic imidazole derivatives, miconazole and econazole were measured. Increased ionization of the imidazole derivatives decreased the size of the stability constants. The same phenomenon was observed for miconazole and hydroxypropyl-beta-cyclodextrin. In addition, the type of solubility diagram obtained was dependent on the degree of ionization of the imidazole derivatives. A type Bs solubility diagram was obtained for econazole and beta-CD in buffer solution, pH 7.1. An econazole beta-CD complex with a molar ratio of 1:1 was isolated. In a fluid medium the antimycotic effect of the econazole beta-CD complex against a strain of Candida albicans was superior to the effect of a physical mixture of the two compounds. A small inhibitory effect of beta-CD on the growth of the test organism was observed.
Synthetic Route of 152628-02-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 152628-02-9.