A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 38668-46-1, Name is 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine, molecular formula is C9H13N7. In an article, author is Ingrand, Sabrina,once mentioned of 38668-46-1, Recommanded Product: 38668-46-1.
The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation
Inhibition of double-stranded RNA-dependent protein kinase (PKR) represents an interesting strategy for neuroprotection. However, inhibiting this kinase which triggers the apoptotic process could favour in counterpart cell proliferation and tumorigenesis. Here, we use an in vivo model of 7-day-old rat displaying a high activation of brain PKR to investigate the effects of a new PKR inhibitor identified as an oxindole/imidazole derivative (06). We show for the first time that acute systemic injection of C16 specifically inhibits the apoptotic PKR/eIF2 alpha signaling pathway without stimulating the proliferative mTOR/p7OS6K signaling mechanism. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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