The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 641571-11-1, Name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, SMILES is CC1=C[N](C=N1)C2=CC(=CC(=C2)N)C(F)(F)F, in an article , author is Cvejn, Daniel, once mentioned of 641571-11-1, COA of Formula: C11H10F3N3.
alpha-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity
alpha-Amino acid-derived 2-phenylimidazole derivatives were designed, synthesized, and further investigated as potential antimycobacterial agents. The synthesis of target imidazole derivatives involved the transformation of Cbz-protected alpha-amino acids (Ala, Val, Phe, Leu, iLe, and Pro) into alpha-diazoketones and alpha-bromoketones, respectively. Subsequent treatment of alpha-bromoketones with (4-nitro)benzamidine afforded imidazole derivatives bearing alpha-amino acid residue appended to the imidazole C4 and (4-nitro)phenyl ring in the position C2. Antimycobacterial activities of both series of compounds against M. tuberculosis, M. avium, and M. kansasii were screened and basic structure-activity relationships were further evaluated.
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