Month: March 2021

Reference of 616-47-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 616-47-7, Name is 1-Methyl-1H-imidazole, SMILES is CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is Wnuk, Malgorzata, introduce new discover of the category.

Prediction of antimicrobial activity of imidazole derivatives by artificial neural networks

The main goal of our study is the analysis of data obtained from molecular modeling for a series of imidazole derivatives that possess strong antifungal activity. The research was designed to use artificial neural network (ANN) analysis to determine quantitative relationships between the structural parameters and anti-Streptococcus pyogenes activity of a series of imidazole derivatives. ANN in association with quantitative structure-activity relationships (QSAR) represents a promising tool in the search for drug candidates among the practically unlimited number of possible derivatives. In this work, a series of 286 imidazole derivatives presented as cationic three-dimensional structures was used. The activity was expressed as a logarithm of the reciprocal of the minimal inhibitory concentrations, log 1/MIC. Multilayer perceptron ANN was used for predictions of antimicrobial potency of new imidazole derivatives on the basis of their structural descriptors. The obtained correlation coefficient equaled 0.9461 for the learning set, 0.9060 for the validation set and 0.8824 for the testing set of imidazole derivatives. Hence, satisfactory and practically useful predictions of anti-Streptococcus pyogenes activity for a series of imidazole derivatives was obtained, supporting the future successful interpretation of QSAR analysis for those compounds.

Reference of 616-47-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 616-47-7 is helpful to your research.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1072-63-5, Name is 1-Vinyl-1H-imidazole, molecular formula is C5H6N2. In an article, author is Olender, Dorota,once mentioned of 1072-63-5, Recommanded Product: 1072-63-5.

Anti-Candida Activity of 4-Morpholino-5-Nitro- and 4,5-Dinitro-Imidazole Derivatives

The activities of some 4-morpholino-5-nitro- and 4,5-dinitro-imidazole derivatives with respect to several Candida species were evaluated. It is established that 4,5-dinitroimidazole derivatives constitute an important group of compounds possessing antifungal activity against Candida species. Some analogs showed moderate antifungal ability in vitro, especially in relation well-known antifungals such as flucytosine (5FC). The best results of antifungal action were obtained for 1-(3-bromo-2-hydroxypropyl)-2-methyl-4,5-dinitroimidazole (3c), 1-(3-bromo-2-oxopropyl)-2-methyl-4,5-dinitroimidazole (4c) and 2-methyl-1-phenacyl-4,5-dinitroimidazole (2b). The latter compound proved to be effective against Candida sake S-1 (in contrast to inactive 5FC).

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In an article, author is Nowak, Ireneusz, once mentioned the application of 152628-02-9, Recommanded Product: 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, Name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, molecular formula is C19H20N4, molecular weight is 304.39, MDL number is MFCD03840857, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

N-oxides of adenosine-type nucleosides undergo pyrimidine ring opening and closure to give 5-amino-4-(1,2,4-oxadiazol-3-yl)imidazole derivatives

Treatment of acylated adenosine N-oxides with carboxylic anhydrides and thiophenol resulted in pyrimidine ring opening followed by exocyclic ring closure. Ammonolysis gave 5-amino-4-(5-substituted-1,2,4-oxadiazol-3-yl)-1-(beta-D-ribofuranosyl) imidazole derivatives, whereas iodine in methanol selectively unmasked the 5-amino group. Related flexible nucleoside analogues can be prepared from adenine-type precursors.

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Synthetic Route of 934-32-7, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, SMILES is NC1=NC2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a article, author is Wan, Li, introduce new discover of the category.

Synthesis, characterization, and electrochemical properties of imidazole derivatives functionalized single-walled carbon nanotubes

The imidazole derivatives functionalized single-walled carbon nanotubes (SWNTs) were synthesized by a diazonium-based reaction. We have designed and synthesized two imidazole derivatives to modify SWNTs. The resulting products were characterized by Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, ultraviolet visible (UV/Vis) spectroscopy, thermo gravimetric analysis (TGA), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), and atomic force microscopy (AFM). Electrochemical measurements via a cyclic voltammetry method revealed that the weak intramolecular electronic interactions presented between the attached imidazole derivatives groups and the nanotubes. Copyright (C) 2008 John Wiley & Sons, Ltd.

Synthetic Route of 934-32-7, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 934-32-7 is helpful to your research.

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 25676-75-9, Name is 4-Bromo-1-methylimidazole. In a document, author is Tseng, Chih-Hua, introducing its new discovery. COA of Formula: C4H5BrN2.

Identification of furo[3 ‘,2 ‘:3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E-2 synthase-1 (mPGES-1)

This study describes the synthesis and anti-inflammatory effects of furo[3′, 2′:3,4]naphtho[1,2-d] imidazole derivatives. Among these furo[3′, 2′:3,4]naphtho[1,2-d]imidazole derivatives, 2-(4-methoxyphenyl)furo [3′, 2’:3,4]naphtho[1,2-d]imidazole (12) exhibited a strong inhibitory activity against LPS-induced PGE(2) production, with an IC50 value of 47 nM. Compound 12 is then further examined for its inhibitory effects in the protein expression of COX-2 and microsomal prostaglandin E-2 synthase-1 (mPGES-1) in Raw 264.7 cells. Our results indicate that compound 12 was capable against inhibiting LPS-induced mPGES-1 protein expression at a concentration of 1.0 mu M and no inhibitory effect in COX-2 expression. The sepsis-induced PGE(2) production in rat serum decreased similar to 250% by the pretreatment of 12 at 10 mg/kg. These results are especially important since compound 12 exhibited good oral bioavailability (72%) and was not cytotoxic at a concentration of 10.0 mu M. Therefore, compound 12 is a highly selective mPGES-1 inhibitor that can serve as a lead for the development of novel oral anti-inflammatory drug candidates.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 25676-75-9 help many people in the next few years. COA of Formula: C4H5BrN2.

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.16079-88-2, Name is 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione, SMILES is O=C1N(Cl)C(C(C)(C)N1Br)=O, belongs to imidazoles-derivatives compound. In a document, author is Kim, Dae-Kee, introduce the new discover, Quality Control of 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione.

Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38 alpha mitogen-activated protein kinase

A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH(2)-substituted benzyl moiety have been synthesized and evaluated for p38 alpha MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38 alpha MAP kinase with IC(50) values 27.6, 28, and 31 nM, respectively. (c) 2008 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 16079-88-2 is helpful to your research. Quality Control of 1-Bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione.

583-39-1, Name is 2-Mercaptobenzimidazole, molecular formula is C7H6N2S, SDS of cas: 583-39-1, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Begunov, R. S., once mentioned the new application about 583-39-1.

Synthesis of pyrido[1,2-a]benzimidazoles and other fused imidazole derivatives with a bridgehead nitrogen atom

Main methods for the synthesis of fused imidazole derivatives with a bridgehead nitrogen atom are systematically considered and summarized. The reaction mechanisms that underlie the methods for the synthesis of pyrido[1,2-a]benzimidazoles and related compounds are described. Biological properties and mechanisms of the biological activity of fused azaheterocycles are discussed. The bibliography includes 152 references.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 583-39-1 help many people in the next few years. SDS of cas: 583-39-1.

Application of 3543-73-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 3543-73-5, Name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, SMILES is O=C(OCC)CCCC1=NC2=CC(N)=CC=C2N1C, belongs to imidazoles-derivatives compound. In a article, author is Jayabharathi, Jayaraman, introduce new discover of the category.

Binding interaction of bioactive imidazole with bovine serum albumin-A mechanistic investigation

A novel Y-shaped imidazole derivative 4-((E)-2-(4,5-diphenyl-1-p-tolyl-1H-imidazol-2-yl)vinyl)phenol has been synthesized and characterised by IR, UV-vis, mass and NMR spectral techniques. The mutual interaction of this imidazole derivative (DPTIV) with bovine serum albumin (BSA) was investigated using photoluminescent studies. The fluorescence quenching mechanism of BSA by DPTIV was analyzed and the binding constant has been calculated. The binding distance between DPTIV and BSA was obtained based on the theory of Forester’s non-radiation energy transfer. The effect of some common ions on the binding constant between DPTIV and BSA was also examined. (C) 2011 Elsevier B.V. All rights reserved.

Application of 3543-73-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 3543-73-5.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 51-17-2, Name is 1H-Benzo[d]imidazole, SMILES is C12=CC=CC=C1N=CN2, in an article , author is Du, Li-Hua, once mentioned of 51-17-2, Application In Synthesis of 1H-Benzo[d]imidazole.

Markovnikov addition of imidazole derivatives with vinyl esters catalyzed by lipase TL IM from Thermomyces lanuginosus/K2CO3 in a continuous-flow microreactor

In this work, a simple and efficient method for Markovnikov addition of imidazole derivatives to vinyl esters catalyzed by Lipozyme TL IM/K2CO3 in a continuous-flow microreactor was described. The effects of the mixed catalysts, molar ratio and the structure of reactants on the reaction performance were experimentally studied. The attractive features of this process are shorter reaction times (30 min) and excellent yields compared to that in shaker reactors.

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Application of 1072-62-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1072-62-4, Name is 2-Ethyl-1H-imidazole, SMILES is CCC1=NC=CN1, belongs to imidazoles-derivatives compound. In a article, author is Wang, Jinchang, introduce new discover of the category.

Electrochemical and Theoretical Study of Imidazole Derivative as Effective Corrosion Inhibitor for Aluminium

The corrosion inhibition performance of 2-styryl-1,8-dihydro-1,3,8-triaza-cyclopentaindene (IIZ) on Aluminium in 1M HCl was investigated by electrochemical impedance spectroscopy (EIS), Potentiodynamic polarization, scanning electron microscopy (SEM), atomic force microscopy (AFM), and quantum chemical techniques. Potentiodynamic polarization study confirmed that IIZ is mixed type inhibitor with cathodic predominance. SEM and AFM confirm the formation of an adsorption film on the aluminium surface. Quantum chemical study reveals that protonated IIZ interacts more than neutral IIZ. The theoretical data obtained are in agreement with experimental results.

Application of 1072-62-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 1072-62-4 is helpful to your research.