Month: March 2021

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 51-17-2, Name is 1H-Benzo[d]imidazole, molecular formula is , belongs to imidazoles-derivatives compound. In a document, author is DEMEO, M, Quality Control of 1H-Benzo[d]imidazole.

EVALUATION OF THE MUTAGENIC AND GENOTOXIC ACTIVITIES OF 48 NITROIMIDAZOLES AND RELATED IMIDAZOLE DERIVATIVES BY THE AMES TEST AND THE SOS CHROMOTEST

The mutagenic and genotoxic activities of 48 nitroimidazoles and related imidazole derivatives have been evaluated by using modified versions of the Ames test and the SOS Chromotest. Salmonella typhimurium tester strain TA 100 was used with and without metabolic activation in the Ames test and Escherichia coli tester Strain PQ 37 was used with and without metabolic activation in the SOS Chromotest. Including metronidazole and dimetridazole, 45 derivatives were mutagenic and genotoxic. The mutagenic potencies (MP) ranged from 0.127 to 53,717 revertants/nmol while the SOS induction powers (SOSIP) ranged from 0.00131 to 107 IF/nmol. The overall correlation between MP and SOSIP was r = 0.845 (n = 84) as calculated by linear regression analysis. A higher correlation was observed between MP and SOSIP without the S9 mix than with it. Among the imidazole derivatives, the 5-nitroimidazoles with a lactam ring at the 2-position showed the highest MP and SOSIP. The presence of a nitro group at the 5-position was critical for the mutagenicity and the genotoxicity of the derivatives. Substituents at the 1- and 2-positions were also found to modulate these activities.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 51-17-2, in my other articles. Quality Control of 1H-Benzo[d]imidazole.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is STUPNISEKLISAC, E, once mentioned the application of 38668-46-1, Name is 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine, molecular formula is C9H13N7, molecular weight is 219.25, MDL number is MFCD00047350, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Name: 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine.

IMIDAZOLE DERIVATIVES AS CORROSION-INHIBITORS FOR ZINC IN HYDROCHLORIC-ACID

The efficiency of various imidazole derivatives as zinc corrosion inhibitors in hydrochloric acid (HCl) was investigated using electrochemical and gravimetric methods. A difference in efficiency (z) was observed with the introduction of different substituents into a imidazole skeleton. It was established that substituents which increased the electron density at the reaction center improved the corrosion inhibiting properties of the heterocyclic compound. A linear correlation between reaction kinetic data and the sum of the polar substituent constants was obtained.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 38668-46-1, Name: 6-(2-(2-Methyl-1H-imidazol-1-yl)ethyl)-1,3,5-triazine-2,4-diamine.

Synthetic Route of 583-39-1, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 583-39-1, Name is 2-Mercaptobenzimidazole, SMILES is SC1=NC2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a article, author is Agelis, George, introduce new discover of the category.

Facile and Efficient Syntheses of a Series of N-Benzyl and N-Biphenylmethyl Substituted Imidazole Derivatives Based on (E)-Urocanic acid, as Angiotensin II AT1 Receptor Blockers

In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential antihypertensive leads. Therefore, new AT1 receptor blockers bearing either the benzyl or the biphenylmethyl moiety at the N-1 or N-3 position, either the (E)-acrylate or the propanoate fragment and their related acids at the C-4 position as well as a halogen atom at the C-5 position of the imidazole ring, were synthesized. The newly synthesized analogues were evaluated for binding to human AT1 receptor. The biological results showed that this class of molecules possesses moderate or no activity, thus not always confirming high docking scores. Nonetheless, important conclusions can be derived for their molecular basis of their mode of action and help medicinal chemists to design and synthesize more potent ones. An aliphatic group as in losartan seems to be important for enhancing binding affinity and activity.

Synthetic Route of 583-39-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 583-39-1.

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Formula: C4H5BrN2, 25676-75-9, Name is 4-Bromo-1-methylimidazole, SMILES is CN1C=NC(Br)=C1, in an article , author is Gupta, Sarita, once mentioned of 25676-75-9.

Synthesis and antimicrobial study of 2-amino-imidazole derivatives

A novel series of 2-amino-imidazole derivatives have been synthesized by conventional method from various di carbonyl compounds with substituted N-phenyl amides in presence of ammonium acetate and glacial acetic acid under reflux conditions with good yields. All the synthesized compounds have been characterized by IR, H-1 and C-13 NMR, mass and elemental analysis in full accordance with their depicted structures. The synthesized products have been screened for antimicrobial activity and the results reveal that introduction of amine at 2nd position of imidazole moiety enhances the antibacterial as well as antifungal activity.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 25676-75-9, you can contact me at any time and look forward to more communication. Formula: C4H5BrN2.

In an article, author is Yue, Shumei, once mentioned the application of 144689-94-1, Name is Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate, molecular formula is C12H18N2O4, molecular weight is 254.28, MDL number is MFCD08062365, category is imidazoles-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate.

Synthesis, crystal structure and luminescent properties of transition metals complexes based on imidazole derivatives

In this paper, we synthesized complexes of imidazole derivatives. The structures of complexes Ni(L1)(2)(CNS)(2) (complex 1), Zn(L2)(2)(CNS)(2) (complex 2) and MnL3Cl2 (complex 3) were determined by X-ray diffraction in those complexes. The space groups of complex 1,2 and 3 are C2c/c, P-1 and P21/n, respectively. Ni (II), Zn (II) ions are coordinated by four nitrogen atoms of ligands and two nitrogen atoms of thiocyanate. Mn(II) ion is coordinated by three nitrogen atoms of ligand and two chlorine atoms. Single crystal X-ray studies on complex 2 and complex 3 indicate that the molecules of the complexes 2 and 3 link together through intermolecular N-H center dot center dot center dot S hydrogen bonds and N-H center dot center dot center dot Cl hydrogen bonds, respectively. The DFT (Density Functional Theory) and luminescent properties of these complexes are discussed. The calculated results are in good agreement with the experimental data. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 144689-94-1, Recommanded Product: Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, molecular formula is C4H6N2O, belongs to imidazoles-derivatives compound, is a common compound. In a patnet, author is Yue, Yuanyuan, once mentioned the new application about 822-55-9, Recommanded Product: 4-(Hydroxymethyl)imidazole.

Synthesis of imidazole derivatives and the spectral characterization of the binding properties towards human serum albumin

Small molecular drugs that can combine with target proteins specifically, and then block relative signal pathway, finally obtain the purpose of treatment. For this reason, the synthesis of novel imidazole derivatives was described and this study explored the details of imidazole derivatives binding to human serum albumin (HSA). The data of steady-state and time-resolved fluorescence showed that the conjugation of imidazole derivatives with HSA yielded quenching by a static mechanism. Meanwhile, the number of binding sites, the binding constants, and the thermodynamic parameters were also measured; the raw data indicated that imidazole derivatives could spontaneously bind with HSA through hydrophobic interactions and hydrogen bonds which agreed well with the results from the molecular modeling study. Competitive binding experiments confirmed the location of binding. Furthermore, alteration of the secondary structure of HSA in the presence of the imidazole derivatives was tested. (C) 2015 Elsevier B.V. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 822-55-9. The above is the message from the blog manager. Recommanded Product: 4-(Hydroxymethyl)imidazole.

Electric Literature of 1072-63-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1072-63-5, Name is 1-Vinyl-1H-imidazole, SMILES is C=CN1C=CN=C1, belongs to imidazoles-derivatives compound. In a article, author is EL-Sharief, Marwa A. M. Sh, introduce new discover of the category.

Synthesis and Evaluation of Antibacterial and Antifungal Activities of 1,3-Disubstituted-4-thioxoimidazolidin-2-one Derivatives

1,3-Disubstituted-4-thioxoimidazolidin-2-one derivatives with various substituents at N(1 )and N-3 were synthesized with high yields and excellent purity by the reaction of various N-arylcyanothioformamide derivatives with isocyanate derivatives. The activity of these products as antibacterial and antifungal agents was studied to through some light on structural activity relationship. Some of synthesized compounds showed significant antibacterial and antifungal activities. Most of the imidazole derivatives possess significant antifungal activity aginst S. cerevisiae (MIC 1-10 mu g mL(-1)). As comparision with ketoconazole, most of the imidazole derivatives showed activity ranging from 50 % less activity to fourfold activity.

Electric Literature of 1072-63-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1072-63-5 is helpful to your research.

In an article, author is Balaji, Kola, once mentioned the application of 3543-73-5, HPLC of Formula: C14H19N3O2, Name is Ethyl 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoate, molecular formula is C14H19N3O2, molecular weight is 261.3196, MDL number is MFCD09840909, category is imidazoles-derivatives. Now introduce a scientific discovery about this category.

Ultrasonic Synthesis, Antimicrobial and Brine Shrimp Lethality Assay of Novel Thiadiazole-Imidazole Derivatives

A facile synthesis of 2, 5-disubstituted thiadiazole derivatives has been achieved by mixing and refluxing/ultrasonicating thiosemicarbazide with various aromatic acids in presence of only conc. sulphuric acid, which were further condensed with p-N, N-dimethyl amino / hydroxyl benzaldehyde to get imino derivatives in a sonicator. These characterized compounds were further reacted with ammonium acetate and bromo-isatin to get biological active potential thiadiazole-imidazole analogues. The structures of all newly synthesized compounds were elucidated by various spectral data. All synthesized compounds were evaluated for antimicrobial and few potential compounds were subjected to brine shrimp lethality bioassay. The detailed synthesis, spectroscopic data and activities has been reported

If you are interested in 3543-73-5, you can contact me at any time and look forward to more communication. HPLC of Formula: C14H19N3O2.

Electric Literature of 822-55-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 822-55-9, Name is 4-(Hydroxymethyl)imidazole, SMILES is OCC1=CNC=N1, belongs to imidazoles-derivatives compound. In a article, author is Navas, JM, introduce new discover of the category.

Induction of cytochrome P4501A (CYPIA) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives

The classical pathway for induction of cytochrome P4501A (CYP1A) by xenobiotics is ligand binding to the aryl hydrocarbon receptor (AhR). High-affinity AhR ligands are planar polyaromatic molecules such as the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The present work investigated the ability of the imidazole derivative, clotrimazole [ 1-(2′ chlorotrityl)imidazole, CLO], to induce CYP1A in cultured rainbow trout (Oncorhynchus mykiss) hepatocytes at the catalytic activity (determined as 7-ethoxyresorufin-O-deethylase, EROD) and at the transcriptional level. CLO resulted in a significant increase of hepatocyte EROD activity and CYP1A mRNA at a concentration of 1.56 muM. Computational studies on the molecular structure of CLO show that CLO is unlikely to take a planar conformation. Further indications that CLO does not behave like a planar AhR ligand come from the experimental observation that co-incubation of trout hepatocytes with CLO and the AhR antagonist, alpha-naphthoflavone (alpha-NF), did not result in an inhibition of CLO induction of CYP1A mRNA, whereas alpha-NF was able to inhibit CYP1A induction by the prototpyic, planar AhR ligand, beta-naphthoflavone. The experimental findings on CLO agree with previous results obtained for another non-planar imidazole derivative, 1-benzylimidazole (B1M). Further, computational studies showed that the non-planar imidazoles, BIM and CLO, are highly similar with respect to some electrostatic properties, namely the dipole moment and the molecular electrostatic potential (MEP). Overall our experimental and computational studies suggest that transcriptional activation of CYP1A by the imidazole derivatives CLO and BIM is mediated by a mechanism different to that of prototypic CYP1A inducers such as the planar AhR-ligands. (C) 2004 Elsevier Inc. All rights reserved.

Electric Literature of 822-55-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 822-55-9.

Reference of 934-32-7, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 934-32-7, Name is 1H-Benzo[d]imidazol-2-amine, SMILES is NC1=NC2=CC=CC=C2N1, belongs to imidazoles-derivatives compound. In a article, author is Jayabharathi, Jayaraman, introduce new discover of the category.

Physicochemical studies of some novel Y-shaped imidazole derivatives – A sensitive chemisensor

Some novel Y-shaped imidazole derivatives were developed for highly sensitive chemisensors for transition metal ions. A prominent fluorescence enhancement was found in the presence of transition metal ions such as Hg2+, Pb2+ and Cu2+ and it is due to the suppression of radiationless transitions from the n-pi* state in the chemisensors. The HOMO-LUMO energies, electric dipole moment (mu) and the first-hyperpolarizability (beta) values of the investigated molecule have been studied theoretically which reveal that the synthesized molecules have microscopic non-linear optical (NLO) behaviour with non-zero values. (C) 2011 Elsevier B.V. All rights reserved.

Reference of 934-32-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 934-32-7.