A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C4H6N2S, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 60-56-0, Name is 1-Methyl-1H-imidazole-2(3H)-thione, molecular formula is C4H6N2S. In an article, author is Gulevich, Anton V.,once mentioned of 60-56-0.
The first example of a diastereoselective thio-Ugi reaction: A new synthetic approach to chiral imidazole derivatives
The first example of a diastereoselective thio-Ugi reaction with chiral a-methylbenzylamine is described. The reaction results in formation of two diastereomers of thioamides, the major of which was isolated. We have found that under similar conditions stereochemical results of the thio-Ugi reaction are opposite to stereochemical results of the Ugi reaction. Several chiral thioamides were synthesized. The reaction of thioamides with ammonia results in substituted amidines, which can be cyclized to imidazole derivatives in aqueous HC1. The synthesis of chiral imidazole derivatives was elaborated. Using certain approaches, both isomers of a key synthon in the synthesis of SB203386 (an orally bioactive HIV-1 protease inhibitor) were prepared. The scope, limitations, and stereochemistry of the approach are discussed.
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