Electric Literature of 2620-76-0,Some common heterocyclic compound, 2620-76-0, name is 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, molecular formula is C19H13BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1.02 g (2.20 mmol) of Intermediate 7-6, 0.69 g (2.20 mmol) of 2-(4-bromophenyl)- 1 -phenyl-1 -benzoimidazole (Compound R-6), 0.127 g (0.11 mmol) of Pd(PPh3)4, and 0.45 g (3.3 mmol) of K2C03 were dissolved in 40 ml of a mixed solution of THF and H20 (a volume ratio of 2:1), andthe resultant solution was stirred at 70¡ã C. for 5 hours. The reaction solution was cooled down to room temperature, 30 ml of water was added thereto, and the resultant solution was then extracted three times with 30 ml of ethylethet The obtained organic layer was dried with magnesium sulfateand a solvent was evaporated therefrom to obtain a crude product. The crude product was purified with silicagel colunm chromatography to obtain 1.01 g of Compound 6 (yield: 76percent). The obtained compound was confirmed by ?H nuclear magnetic resonance (NMR) and MS/FAR.?H NMR (CDC13, 400 MHz) D oe: 8.82-8.78 (m, 4H), 8.28(dd, 1H), 7.98-7.96 (m, 1H), 7.85 (d, 1H), 7.73 (d, 1H),7.67-7.59 (m, 6H), 7.53-7.47 (m, 2H), 7.43-7.37 (m, 4H),7.35-7.33 (m, 1H), 1.45 (s, 6H), 1.35 (s, 6H) C45H35N2: calc. 604.28. found 605.33.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(4-Bromophenyl)-1-phenyl-1H-benzoimidazole, its application will become more common.
Reference:
Patent; Samsung Display Co., Ltd.; Jung, Hye-Jin; Hwang, Seok-Hwan; Kim, Young-Kook; Lim, Jin-O; Han, Sang-Hyun; Jeong, Eun-Jae; Kim, Soo-Yon; Park, Jun-Ha; Lee, Eun-Young; Lee, Chang-Ho; Lee, Jong-Hyuk; (73 pag.)US9537104; (2017); B2;,
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